Preparation and Characterization of Pioglitazone Hcl Solid Inclusion Complex - an Solubility Enhancement Technique

نویسندگان

  • Bhuvaneswara Rao
  • Chandra Sekhar
چکیده

Pioglitazone is an anti-diabetic drug in high blood sugar in patients with type 2 diabetes (non-insulin-dependent diabetes) which was belongs to poor aqueous solubility and bioavailable drug. By using β Cyclodextrin, the solubility and dissolution rate of Pioglitazone HCL can be enhanced and it was evaluated by synthesizing it into solid inclusion complexes in different ratio of drug: β cyclodextrin. Phase solubility study was carried out to optimize the solubility of free drug and complex formed drug. Solid inclusion complexes were prepared by using kneading method. The formulated complexes were evaluated by Fourier transform infrared spectroscopy (FT-IR) to know the changes in crystallization. From the in-vitro studies it was concluded that there was an increase in solubility and dissolution rate of Pioglitazone HCL on complexation with beta-cyclodextrin. The study revealed that complexation of Pioglitazone HCL with beta-cyclodextrin effectively enhanced the aqueous solubility and bioavailability in systemic circulation.

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تاریخ انتشار 2014